The body's immune response fights against infectious disease, and it safeguards against future infections through vaccination. However, if the immune response dysfunctions and attacks the body itself, it can cause autoimmune disease. Thus, a healthy immune response balances an instant readiness to combat infecting viruses or bacteria, while maintaining benign surveillance of the body's own tissues.
A key player in the immune response is T follicular helper cells. These Tfh cells are essential in vaccination responses, but they can be harmful actors in an autoimmune disease like lupus.
Now, a preclinical study published in Science Immunology shows how ...
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