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Pulling the plug on calcium pumps -- potential new treatment strategy for pancreatic cancer


UK scientists have identified a new way to kill pancreatic cancer cells by 'pulling the plug' on the energy generator that fuels calcium pumps on their cell surface. The study, published in the British Journal of Cancer, reports how switching off the cancer's energy supply causes the pancreatic cancer cells to become 'poisoned' by an irreversible build-up of calcium.

Calcium inside cells is normally beneficial as it controls numerous cell functions. However, calcium levels are tightly controlled and normally kept at very low levels, as prolonged elevations in calcium lead to cell death. This tight control is achieved by ...


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